Linkage disequilibrium and age of HLA region SNPs in relation to classic HLA gene alleles within Europe.

Journal article

The HLA region on chromosome 6 is gene-rich and under selective pressure because of the high proportion of immunity-related genes. Linkage disequilibrium (LD) patterns and allele frequencies in this region are highly differentiated across broad geographical populations, making it a region of interest for population genetics and immunity-related disease studies. We examined LD in this important region of the genome in six European populations using 166 putatively neutral SNPs and the classical...

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Authors: Evseeva, I; Nicodemus, K; Bonilla, C; Tonks, S; Bodmer, W

• Publication status: Published
• Journal: European journal of human genetics : EJHG
• Volume: 18
• Issue: 8
• Pages: 924-932
• Publication date: 2010-08-01
• DOI: 10.1038/ejhg.2010.32
• EISSN: 1476-5438
• ISSN: 1018-4813
• Language: English
• Keywords: Genetics, Population; Humans; Genotype; Europe; Haplotypes; Genetic Variation; Chromosomes, Human, Pair 6; European Continental Ancestry Group; Chromosome Mapping; Polymorphism, Single Nucleotide; Linkage Disequilibrium; HLA Antigens; Gene Frequency