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Journal article

Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.

Abstract:

In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is no...

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Publication status:
Published

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Publisher copy:
10.1186/ar2574

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Arthritis research and therapy
Volume:
11
Issue:
1
Pages:
213
Publication date:
2009-01-01
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
Source identifiers:
226577
Language:
English
Keywords:
Pubs id:
pubs:226577
UUID:
uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef
Local pid:
pubs:226577
Deposit date:
2013-11-16

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