- Abstract:
-
In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is no...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1186/ar2574
-
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- Journal:
- Arthritis research and therapy
- Volume:
- 11
- Issue:
- 1
- Pages:
- 213
- Publication date:
- 2009
- DOI:
- EISSN:
-
1478-6362
- ISSN:
-
1478-6354
- URN:
-
uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef
- Source identifiers:
-
226577
- Local pid:
- pubs:226577
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.
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