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Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.

Abstract:

In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is no...

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Publication status:
Published

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Publisher copy:
10.1186/ar2574

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Vaghjiani, RJ More by this author
Lafont, JE More by this author
Journal:
Arthritis research and therapy
Volume:
11
Issue:
1
Pages:
213
Publication date:
2009
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef
Source identifiers:
226577
Local pid:
pubs:226577

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