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Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.

Abstract:

Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Annals of human genetics
Volume:
70
Issue:
Pt 6
Pages:
726-737
Publication date:
2006-11-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:83baa2af-9ccc-4817-9a50-ff04daa9dfb0
Source identifiers:
23763
Local pid:
pubs:23763

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