Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates.

Journal article

We have compared the ability of phencyclidine (PCP)-like or sigma ligands to induce psychomotor effects in primates. In squirrel monkeys, administration of MK-801 (0.001-0.1 mg/kg), PCP (0.03-0.3 mg/kg), (+)-SKF10047 (0.001-3.0 mg/kg) or (-)-SKF10047 (0.1-10 mg/kg) induced ataxia, head weaving and bradykinesia. In contrast, treatment with the selective sigma ligand (+)-pentazocine using doses up to 20 mg/kg failed to induce any overt behaviours. The order of potency for induction of these beh...

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Authors: Boyce, S; Rupniak, N; Steventon, M; Cook, G; Iversen, S

• Publication status: Published
• Journal: Behavioural brain research
• Volume: 42
• Issue: 2
• Pages: 115-121
• Publication date: 1991-02-01
• DOI: 10.1016/s0166-4328(05)80002-6
• EISSN: 1872-7549
• ISSN: 0166-4328
• Language: English
• Keywords: Receptors, Opioid; Male; Receptors, N-Methyl-D-Aspartate; Phencyclidine; Dizocilpine Maleate; Pentazocine; Space Perception; Macaca mulatta; Phenazocine; Cognition; Psychomotor Performance; Animals; Saimiri; Receptors, sigma; Ataxia