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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Abstract:

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy...

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Publisher copy:
10.1038/ng.686

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Journal:
Nature genetics
Volume:
42
Issue:
11
Pages:
937-948
Publication date:
2010-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:83b21963-ea10-4363-a160-3808b6c4b4c1
Source identifiers:
85832
Local pid:
pubs:85832

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