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Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

Abstract:

Background: Multiplex assays are increasingly applied to analyze multicomponent signatures of human immune responses, including the dynamics of cytokine and chemokine production, in observational as well as interventional studies following treatment or vaccination. However, relatively limited information is available on the performance of the different available multiplex kits, and comparative evaluations addressing this important issue are lacking.

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0201205

Authors


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Role:
Author
ORCID:
0000-0003-2818-9805
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Funding agency for:
McShane, H
Grant:
643381EC
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Funding agency for:
Ho, MM
Grant:
312661
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Funding agency for:
Dockrell, HM
Grant:
643381EC
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Funding agency for:
Ottenhoff, THM
Grant:
643381EC
Publisher:
Public Library of Science Publisher's website
Journal:
PloS ONE Journal website
Volume:
13
Issue:
9
Article number:
e0201205
Publication date:
2018-09-04
Acceptance date:
2018-07-09
DOI:
EISSN:
1932-6203
Pmid:
30180167
Source identifiers:
912422
Language:
English
Pubs id:
pubs:912422
UUID:
uuid:83a961a1-132e-4d9c-92db-df79c7e9c21b
Local pid:
pubs:912422
Deposit date:
2018-09-20

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