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Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms.

Abstract:

We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed suboptimal decisions (correlated with years of abuse), and deliberat...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
20
Issue:
4
Pages:
322-339
Publication date:
1999-04-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:839c4d25-85a0-4a6c-a75c-0d9d2f24920f
Source identifiers:
223168
Local pid:
pubs:223168

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