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Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions

Abstract:

The prevention of parasite transmission from the human host to the mosquito has been recognized as a vital tool for malaria eradication campaigns. However, transmission-blocking antimalarial drug and/or vaccine discovery and development is currently hampered by the expense and difficulty of producing mature Plasmodium falciparum gametocytes in vitro-the parasite stage responsible for mosquito infection. Current protocols for P. falciparum gametocyte culture usually require complex parasite sy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nprot.2016.096

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Protocols Journal website
Volume:
11
Issue:
9
Pages:
1668-1680
Publication date:
2016-09-05
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Pubs id:
pubs:640677
URN:
uri:8398bf2a-4805-48fa-8ad0-e0a1f68befef
UUID:
uuid:8398bf2a-4805-48fa-8ad0-e0a1f68befef
Local pid:
pubs:640677
Paper number:
9

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