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Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner.

Abstract:

Embryonic stem cells and embryonal carcinoma P19 cells produce erythropoietin (Epo) in an oxygen-independent manner, although lactate dehydrogenase A (LDHA) is hypoxia-inducible. To explore this paradox, we studied the operation of cis-acting sequences from these genes in P19 and Hep3B cells. The Epo gene promoter and 3' enhancer from P19 cells conveyed hypoxia-inducible responses in Hep3B cells but not in P19 cells. Together with DNA sequencing and the normal transcription start site of P19 ...

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Publication status:
Published

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Journal:
Blood
Volume:
91
Issue:
4
Pages:
1185-1195
Publication date:
1998-02-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:839588da-7714-49d6-92a5-402967232bfb
Source identifiers:
74025
Local pid:
pubs:74025

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