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Double dissociation of value computations in orbitofrontal and anterior cingulate neurons.

Abstract:

Damage to prefrontal cortex (PFC) impairs decision-making, but the underlying value computations that might cause such impairments remain unclear. Here we report that value computations are doubly dissociable among PFC neurons. Although many PFC neurons encoded chosen value, they used opponent encoding schemes such that averaging the neuronal population extinguished value coding. However, a special population of neurons in anterior cingulate cortex (ACC), but not in orbitofrontal cortex (OFC)...

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Publication status:
Published online

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Publisher copy:
10.1038/nn.2961

Authors


Kennerley, SW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Wallis, JD More by this author
Journal:
Nature neuroscience
Volume:
14
Issue:
12
Pages:
1581-1589
Publication date:
2011-12-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:8365c6fd-ae8d-433f-8bdb-aa103dad3011
Source identifiers:
222581
Local pid:
pubs:222581

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