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The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications.

Abstract:

This paper puts the case for the hippocampus as being central to the neuropathology and pathophysiology of schizophrenia. The evidence comes from a range of approaches, both in vivo (neuropsychology, structural and functional imaging) and post mortem (histology, morphometry, gene expression, and neurochemistry). Neuropathologically, the main positive findings concern neuronal morphology, organisation, and presynaptic and dendritic parameters. The results are together suggestive of an altered ...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-003-1761-y

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Psychopharmacology
Volume:
174
Issue:
1
Pages:
151-162
Publication date:
2004-06-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:835e51ad-4edf-4021-85d7-e544aa28e426
Source identifiers:
98062
Local pid:
pubs:98062

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