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Antibacterial effect and DNA delivery using a combination of an arsonium-containing lipophosphoramide with an N-heterocyclic carbene-silver complex - Potential benefits for cystic fibrosis lung gene therapy

Abstract:

Cystic Fibrosis (CF), the most common chronic genetic disorder among the Caucasian population, is a life-threatening disease mainly due to respiratory failures resulting from chronic infections and inflammation. Although research in the pharmacological field has recently made significant progress, gene therapy still remains a promising strategy to cure CF, especially because it should be applicable to any patient whatever the mutation profile. Until now, little attention has been paid to bact...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Mottais, A More by this author
Berchel, M More by this author
Sibiril, Y More by this author
Laurent, V More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Oxford college:
University College
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French Muscular Dystrophy Association More from this funder
Vaincre la Mucoviscidose More from this funder
Association of Blood Transfusion and Biogenetics Gaétan Saleün More from this funder
Brittany Region More from this funder
University of Brest More from this funder
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Pharmaceutics Journal website
Volume:
536
Issue:
1
Pages:
29-41
Publication date:
2017-11-10
Acceptance date:
2017-11-10
DOI:
EISSN:
1873-3476
ISSN:
0378-5173
Pubs id:
pubs:746021
URN:
uri:83583f11-6ef5-4322-9b7f-a2df324a5a1c
UUID:
uuid:83583f11-6ef5-4322-9b7f-a2df324a5a1c
Local pid:
pubs:746021

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