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Journal article

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.

Abstract:

UNLABELLED: Hepatitis C virus (HCV) replication in primary liver cells is less robust than that in hepatoma cell lines, suggesting that innate antiviral mechanisms in primary cells may limit HCV replication or spread. Here we analyzed the expression of 47 genes associated with interferon (IFN) induction and signaling following HCV infection of primary human fetal liver cell (HFLC) cultures from 18 different donors. We report that cell culture-produced HCV (HCVcc) induced expression of Type II...

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Publisher copy:
10.1002/hep.24580

Authors


Marukian, S More by this author
Sheahan, TP More by this author
Charles, ED More by this author
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Journal:
Hepatology (Baltimore, Md.)
Volume:
54
Issue:
6
Pages:
1913-1923
Publication date:
2011-12-29
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:8354e504-15dd-4db0-8e25-2fbc77a0e302
Source identifiers:
426219
Local pid:
pubs:426219

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