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Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.

Abstract:

The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2 (N-Oct-3, POU3F2) transcription factor also regulates melanoma proliferation and is up-regulated by BRAF and beta-catenin, two key melanoma-associated signaling molecules. Here, we show that Brn-2 ...

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Publication status:
Published

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Journal:
Cancer research
Volume:
68
Issue:
19
Pages:
7788-7794
Publication date:
2008-10-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:834a0ac9-0686-4a0e-99d7-c81f4e30ffa8
Source identifiers:
53959
Local pid:
pubs:53959

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