Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape.

Journal article

The multidrug-resistant Streptococcus pneumoniae Taiwan(19F)-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, "vaccine escape" PMEN14 isolates with a 19A serotype became an increasingly important cause of disease post-PCV7. Whole genome sequencing was used to characterize the recent evolution of 173 pneumococci of, or related to, PMEN14. This suggested that PMEN14 is a single lineage that origin...

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Authors: Croucher, N; Chewapreecha, C; Hanage, W; Harris, SR; McGee, L

• Publication status: Published
• Journal: Genome biology and evolution
• Volume: 6
• Issue: 7
• Pages: 1589-1602
• Publication date: 2014-07-01
• DOI: 10.1093/gbe/evu120
• EISSN: 1759-6653
• ISSN: 1759-6653
• Language: English
• Keywords: recombination; bacterial evolution; vaccine escape; selective sweeps; antibiotic resistance; phylogenomics