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The centrosome and the DNA damage induced checkpoint.

Abstract:

The centrosome, the microtubule-organizing center of the cell, acts as a localization point, where signaling molecules are able to interact. Many kinases and phosphatases critical for regulation of DNA damage signaling pathways localize to the centrosome. This review will discuss the possible involvement of the centrosome in mediating DNA damage checkpoint control, in particular the effect of DNA damage signaling pathways involved in initiation or maintenance of cell cycle arrest on the centr...

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Publication status:
Published

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Authors


Fletcher, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Cancer letters
Volume:
243
Issue:
1
Pages:
1-8
Publication date:
2006-11-05
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:83427bb3-0446-424b-9b05-3105332eb983
Source identifiers:
131080
Local pid:
pubs:131080

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