- Abstract:
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The readily releasable pool (RRP) of vesicles is a core concept in studies of presynaptic function. However, operating principles lack consensus definition and the utility for quantitative analysis has been questioned. Here we confirm that RRPs at calyces of Held from 14 to 21 day old mice have a fixed capacity for storing vesicles that is not modulated by Ca2+. Discrepancies with previous studies are explained by a dynamic flow-through pool, established during heavy use, contai...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.1371/journal.pcbi.1004855
-
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- Publisher:
- PLoS Publisher's website
- Journal:
- PLoS computational biology Journal website
- Volume:
- 12
- Issue:
- 4
- Pages:
- e1004855
- Publication date:
- 2016-04-01
- Acceptance date:
- 2016-03-07
- DOI:
- EISSN:
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1553-7358
- ISSN:
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1553-734X
- Pubs id:
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pubs:614587
- URN:
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uri:833ac2fb-74e4-4f35-9378-7fcf3157191a
- UUID:
-
uuid:833ac2fb-74e4-4f35-9378-7fcf3157191a
- Local pid:
- pubs:614587
- Language:
- English
- Keywords:
- Copyright holder:
- Mahfooz et al.
- Copyright date:
- 2016
- Notes:
- © 2016 Mahfooz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
A well-defined readily releasable pool with fixed capacity for storing vesicles at calyx of Held.
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