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A well-defined readily releasable pool with fixed capacity for storing vesicles at calyx of Held.

Abstract:

The readily releasable pool (RRP) of vesicles is a core concept in studies of presynaptic function. However, operating principles lack consensus definition and the utility for quantitative analysis has been questioned. Here we confirm that RRPs at calyces of Held from 14 to 21 day old mice have a fixed capacity for storing vesicles that is not modulated by Ca2+. Discrepancies with previous studies are explained by a dynamic flow-through pool, established during heavy use, contai...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1371/journal.pcbi.1004855

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Department:
Oxford, MSD, Pharmacology
Role:
Author

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Role:
Editor
Publisher:
PLoS Publisher's website
Journal:
PLoS computational biology Journal website
Volume:
12
Issue:
4
Pages:
e1004855
Publication date:
2016-04-01
Acceptance date:
2016-03-07
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Pubs id:
pubs:614587
URN:
uri:833ac2fb-74e4-4f35-9378-7fcf3157191a
UUID:
uuid:833ac2fb-74e4-4f35-9378-7fcf3157191a
Local pid:
pubs:614587

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