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Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.

Abstract:

OBJECTIVES: The purpose of this study was to evaluate the role of the myocardial redox state in the development of in-hospital complications after cardiac surgery and the effect of statins on the myocardial redox state. BACKGROUND: Statins improve clinical outcome after cardiac surgery, but it is unclear whether they exert their effects by modifying the myocardial redox state. METHODS: We quantified myocardial superoxide anion (O(2)(-)) and peroxynitrite (ONOO(-)) and their enzymatic sources ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jacc.2011.08.062

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Journal:
Journal of the American College of Cardiology
Volume:
59
Issue:
1
Pages:
60-70
Publication date:
2012-01-05
DOI:
EISSN:
1558-3597
ISSN:
0735-1097
URN:
uuid:83367626-360c-4c64-9d02-b51ed8a4bd9b
Source identifiers:
222319
Local pid:
pubs:222319

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