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Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression.

Abstract:

The ability to identify oocytes with the greatest potential for producing a viable embryo would be of great benefit to assisted reproductive treatments. One of the most important defects affecting oocytes is aneuploidy. Aneuploidy is also closely related with advancing maternal age, a phenomenon not well understood. This study combined a comprehensive cytogenetic investigation of 21 oocytes with a detailed assessment of their transcriptome. The first polar body was removed from all oocytes an...

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Publication status:
Published

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Publisher copy:
10.1093/molehr/gaq033

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Journal:
Molecular human reproduction
Volume:
16
Issue:
8
Pages:
570-582
Publication date:
2010-08-05
DOI:
EISSN:
1460-2407
ISSN:
1360-9947
URN:
uuid:8332b588-5fa7-44d5-a313-bcd29a4017dc
Source identifiers:
248257
Local pid:
pubs:248257

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