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Journal article

Stimulus-secretion coupling in pancreatic beta cells.

Abstract:

Insulin secretion is triggered by a rise in the intracellular Ca2+ concentration that results from the activation of voltage-gated Ca2+ channels in the beta-cell plasma membrane. Multiple types of beta-cell Ca2+ channel have been identified in both electrophysiological and molecular biological studies, but it appears that the L-type Ca2+ channel plays a dominant role in regulating Ca2+ influx. Activity of this channel is potentiated by protein kinases A and C and is inhibited by GTP-binding p...

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Publication status:
Published

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Publisher copy:
10.1002/jcb.240550007

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Ammälä, C More by this author
Bokvist, K More by this author
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Journal:
Journal of cellular biochemistry
Volume:
55 Suppl
Issue:
SUPPL.
Pages:
54-65
Publication date:
1994-01-05
DOI:
EISSN:
1097-4644
ISSN:
0730-2312
URN:
uuid:832fe117-97fe-4ef2-84ba-0d3f49f62ad1
Source identifiers:
5765
Local pid:
pubs:5765

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