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Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation.

Abstract:

High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition. We started from the hypothesis that the effects of electrical stimulation on essential tremor may be phase dependent, and that, in particular, there are tremor phases at which stimuli preferentially lead to a reduction in the amplitude of tremor. The latter could b...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awt239

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Brittain, JS More by this author
Foltynie, T More by this author
Limousin, P More by this author
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Journal:
Brain : a journal of neurology
Volume:
136
Issue:
Pt 10
Pages:
3062-3075
Publication date:
2013-10-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:832d8da5-081b-4568-acf5-54b24bf248da
Source identifiers:
429255
Local pid:
pubs:429255

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