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Journal article

Dynamic regulatory network controlling TH17 cell differentiation.

Abstract:

Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term responses and relied on perturbation-based approaches that cannot be readily applied to primary T cells. Here we combine transcriptional profiling at high temporal resolution, novel computational algorithms, and innovative nanowire-based perturbation tools to systematically...

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Publication status:
Published

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Publisher copy:
10.1038/nature11981

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Journal:
Nature
Volume:
496
Issue:
7446
Pages:
461-468
Publication date:
2013-04-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836

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