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Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival.

Abstract:

PURPOSE: A regulated p53-dependent stress response is crucial in suppressing tumor formation and mediating the response to commonly used cancer therapeutics. However, little is known about the human, inherited genetics of this important signaling pathway. EXPERIMENTAL DESIGN: Studies of human genetic variants in the p53 tumor suppressor gene and MDM2 oncogene have shown that single nucleotide polymorphisms (SNP) can affect p53 signaling, confer cancer risk, and alter outcome, and also sugges...

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Publication status:
Published

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Authors


Grochola, LF More by this author
Vazquez, A More by this author
Taubert, H More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
15
Issue:
19
Pages:
6301-6308
Publication date:
2009-10-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:831fa035-c272-4b7e-8ca2-0f27c77be577
Source identifiers:
69621
Local pid:
pubs:69621

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