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Transcriptomics of cortical gray matter thickness decline during normal aging

Abstract:

Introduction: We performed a whole-transcriptome correlation analysis, followed by the pathway enrichment and testing of innate immune response pathway analyses to evaluate the hypothesis that transcriptional activity can predict cortical gray matter thickness (GMT) variability during normal cerebral aging.

Methods: Transcriptome and GMT data were available for 379 individuals (age range = 28–85) community-dwelling members of large extended Mexican American familie...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Kochunov, P More by this author
Charlesworth, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Nichols, TE More by this author
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Publisher:
Elsevier Inc. Publisher's website
Journal:
NeuroImage Journal website
Volume:
82
Pages:
273-283
Publication date:
2013-11-15
DOI:
ISSN:
1053-8119
URN:
uuid:831e2349-46e1-48e5-b89b-22060fed67d8
Source identifiers:
446007
Local pid:
pubs:446007
Language:
English
Keywords:
Subjects:

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