DNA charge neutralization by linear polymers. II. Reversible binding.

Journal article

We model the way in which polymers bind to DNA and neutralize its charged backbone by analyzing the dynamics of the distribution of gaps along the DNA. We generalize existing theory for irreversible binding to construct deterministic models which include polymer removal, movement along the DNA, and allow for binding with overlaps. We show that reversible binding alters the capacity of the DNA for polymers by allowing the rearrangement of polymer positions over a longer time scale than when bi...

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Authors: Maltsev, E; Wattis, J; Byrne, H

• Journal: Physical review. E, Statistical, nonlinear, and soft matter physics
• Volume: 74
• Issue: 4 Pt 1
• Pages: 041918
• Publication date: 2006-10-01
• DOI: 10.1103/physreve.74.041918
• EISSN: 1550-2376
• ISSN: 1539-3755
• Language: English
• Keywords: Computer Simulation; Binding Sites; Motion; Models, Molecular; DNA-Binding Proteins; Static Electricity; Models, Chemical; Linear Models; Protein Binding; Polymers; DNA