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Increased osteoclastic activity in acute Charcot's osteoarthropathy: the role of receptor activator of nuclear factor-kappaB ligand

Abstract:

Aims/hypothesis: Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). Methods: Peripheral blood monocytes isolated from nine diabetic Charcot patients, eight diabetic control and eight healthy control participants were cultured in the presence of macrophage-colony stimulat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00125-008-0992-1

Authors


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Institution:
University of Oxford
Research group:
Bone cell biology
Department:
Medical Sciences Division - Orthopaedic Surgery
More by this author
Institution:
"King's College Hospital NHS Foundation Trust, London"
Department:
Diabetic Foot Clinic
More by this author
Institution:
"King's College Hospital NHS Foundation Trust, London"
Department:
Diabetic Foot Clinic
More by this author
Institution:
University of Oxford
Research group:
Bone cell biology
Department:
Medical Sciences Division - Orthopaedic Surgery
More from this funder
Funding agency for:
G. Mabilleau
Publisher:
Springer-Verlag Publisher's website
Journal:
Diabetologia Journal website
Volume:
51
Issue:
6
Pages:
1035-1040
Publication date:
2008-06-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:8313bfd6-87f3-448e-a360-af79db318f73
Local pid:
ora:2409

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