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Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice.

Abstract:

Annexin 1 (ANXA1) is a member of the annexin family of phospholipid- and calcium-binding proteins with a well demonstrated role in early delayed (30 min to 3 h) inhibitory feedback of glucocorticoids in the hypothalamus and pituitary gland. This study used adrenal gland tissue from ANXA1-null transgenic mice, in which a beta-galactosidase (beta-Gal) reporter gene was controlled by the ANXA1 promoter, and wild-type control mice to explore the potential role of ANXA1 in adrenal function. RT-PCR...

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Publisher copy:
10.1210/en.2006-0732

Authors


Buckingham, JC More by this author
Morris, JF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Endocrinology
Volume:
148
Issue:
3
Pages:
1030-1038
Publication date:
2007-03-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:8305a9ca-9e80-4e3a-be44-48124defb929
Source identifiers:
114371
Local pid:
pubs:114371

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