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A short primer on early molecular and cellular events in thymus organogenesis and replacement.

Abstract:
Haematopoietic precursors have to undergo a complex series of maturational steps in the thymus before they exit into the periphery as functional T lymphocytes. Thymic stroma cells, the majority being of epithelial origin, provide the functional partners for the maturational progression along this differentiation pathway. Here we review some of the molecular and cellular mechanisms that account for thymus organogenesis and discuss a strategy to use thymic epithelial precursor cells for the regeneration of the thymic microenvironment.

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Authors


Barthlott, T More by this author
Keller, MP More by this author
Krenger, W More by this author
Holländer, GA More by this author
Journal:
Swiss medical weekly
Volume:
137 Suppl 155
Issue:
SUPPL. 155
Pages:
9S-13S
Publication date:
2007-03-05
EISSN:
1424-3997
ISSN:
1424-7860
URN:
uuid:83005495-9c9e-46eb-b303-f5a4f86660a4
Source identifiers:
309027
Local pid:
pubs:309027
Language:
English
Keywords:

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