Journal article
A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.
- Abstract:
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The MR1 antigen-presenting system is conserved among mammals and enables T cells to recognize small molecules produced by bacterial pathogens, including Mycobacterium tuberculosis (M.tb). However, it is not known if MR1-mediated antigen presentation is important for protective immunity against mycobacterial disease. We hypothesized that genetic control of MR1 expression correlates with clinical outcomes of tuberculosis infection. We performed an MR1 candidate gene association study and ide...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Preview, Accepted manuscript, pdf, 451.4KB, Terms of use)
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- Publisher copy:
- 10.1038/gene.2016.41
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Genes & Immunity More from this journal
- Volume:
- 18
- Pages:
- 8-14
- Publication date:
- 2016-11-01
- Acceptance date:
- 2016-10-11
- DOI:
- ISSN:
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1476-5470
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:664028
- UUID:
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uuid:830046a0-219b-4bc6-80e9-80a761f34406
- Local pid:
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pubs:664028
- Source identifiers:
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664028
- Deposit date:
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2016-12-07
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2016
- Notes:
- © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved
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