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T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection.

Abstract:

T cells specific for a single viral epitope, but using different T cell receptors, should have flexibility in their epitope recognition to protect the infected host against the emergence of viral escape mutants. Therefore, polyclonality of the hepatitis B virus (HBV)-specific cytotoxic T lymphocyte response has been hypothesized to be a major determinant in the control of infection. We analyzed the Vbeta chain composition of the core 18-27-specific CD8 cells in acute and persistently HBV-infe...

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Publication status:
Published

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Authors


Reignat, S More by this author
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Journal:
European journal of immunology
Volume:
30
Issue:
11
Pages:
3067-3078
Publication date:
2000-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:82fc6d85-70e8-419a-ba4b-13ea9dd83d0f
Source identifiers:
11714
Local pid:
pubs:11714

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