Journal article
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
- Abstract:
-
The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclerosis and cancer. We report the inhibition of these unusual receptor tyrosine kinases by the multi-targeted cancer drugs imatinib and ponatinib, as well as the selective type II inhibitor DDR1-IN-1. ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.jmb.2014.04.014
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Authors
Bibliographic Details
- Journal:
- Journal of molecular biology
- Volume:
- 426
- Issue:
- 13
- Pages:
- 2457-2470
- Publication date:
- 2014-06-01
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- Source identifiers:
-
463270
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:463270
- UUID:
-
uuid:82fa4c24-cd5d-4b93-bed4-a30bd9a70a87
- Local pid:
- pubs:463270
- Deposit date:
- 2014-06-17
Terms of use
- Copyright date:
- 2014
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