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How homologous recombination maintains telomere integrity

Abstract:

Telomeres protect the ends of linear chromosomes against loss of genetic information and inappropriate processing as damaged DNA and are therefore crucial to the maintenance of chromosome integrity. In addition to providing a pathway for genome-wide DNA repair, homologous recombination (HR) plays a key role in telomere replication and capping. Consistent with this, the genomic instability characteristic of HR-deficient cells and tumours is driven in part by telomere dysfunction. Here, we disc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00412-014-0497-2

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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Funding agency for:
Tacconi, EMC
Cancer Research UK More from this funder
European Molecular Biology Organization More from this funder
Royal Society More from this funder
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Chromosoma Journal website
Volume:
124
Issue:
2
Pages:
119-130
Publication date:
2015-01-01
DOI:
EISSN:
1432-0886
ISSN:
0009-5915
URN:
uuid:82ec0ba7-a17d-4be2-bcc6-283d38bab522
Source identifiers:
526608
Local pid:
pubs:526608

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