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Thesis

Dual roles of p97 in DNA damage repair

Abstract:

An organism’s genome is perpetually challenged by multiple types of DNA lesions. The variety of insults is reflected by an equally diverse range of overlapping DNA repair mechanisms essential for an organism to survive. One protein which has roles in multiple DNA damage repair (DDR) pathways is the segregase/unfoldase p97. p97 acts in a ubiquitin dependent manner to unfold and remove modified substrates, facilitating the enzyme cascades required for efficient DNA damage repair. We show her...

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Role:
Contributor
Role:
Contributor
Role:
Contributor
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
ORCID:
0000-0001-5522-021X
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Name:
Medical Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-06-16

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