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Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells.

Abstract:

CD8(+) T cells are major players in antiviral immunity against human immunodeficiency virus type 1 (HIV-1) through recognition of viral epitopes presented on the surface of infected cells. However, the early events involving HIV-1 epitope presentation to CD8(+) T cells remain poorly understood but are nonetheless crucial for the rapid clearance of virus-infected cells. Here, we comprehensively studied the kinetics of antigen presentation of two protective epitopes, KF11Gag and KK10Gag, restri...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02131-12

Authors


Kløverpris, HN More by this author
Rasaiyaah, JT More by this author
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Journal:
Journal of virology
Volume:
87
Issue:
5
Pages:
2628-2638
Publication date:
2013-03-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:82e55a93-1d43-49a8-a27e-1cc7e275f3c3
Source identifiers:
367747
Local pid:
pubs:367747

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