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Major TCR repertoire perturbation by immunodominant HLA-B*44:03-restricted CMV-specific T cells

Abstract:

Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response. The composition of the T cell receptor (TCR) repertoire underlying this response remains poorly characterised, especially within African populations in which CMV is endemic from infancy. Here we focus on the immunodominant CD8+ T cell response to the immediate-early 2 (IE-2)-derived epitope NEGVKAAW (NW8) restricted by HLA-B*44:03, a highly prevalen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3389/fimmu.2018.02539

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Severinsen, MC More by this author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
2539
Publication date:
2018-11-14
Acceptance date:
2018-10-15
DOI:
EISSN:
1664-3224
Pubs id:
pubs:946907
URN:
uri:82e4263a-0f0d-4563-97fe-293972a7d6e0
UUID:
uuid:82e4263a-0f0d-4563-97fe-293972a7d6e0
Local pid:
pubs:946907

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