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Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase

Abstract:

Stearoyl-CoA desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism, but little is known about its nutritional regulation. Dietary methionine restriction in rats decreases hepatic Scd1 mRNA and protein, increases energy expenditure, and decreases fat-pad mass/body-weight% (FM/BW%). In humans, plasma concentrations of the methionine product, cysteine, are associated with obesity. To determine which consequences of methionine-restriction are mediated by decreased cysteine avail...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1194/jlr.M010215

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of lipid research Journal website
Volume:
52
Issue:
1
Pages:
104-112
Publication date:
2011-01-01
DOI:
EISSN:
1539-7262
ISSN:
0022-2275
Pmid:
20871132
Source identifiers:
195503
Language:
English
Keywords:
Pubs id:
pubs:195503
UUID:
uuid:82e413bc-bf84-4f71-bd4a-684e2d6cf652
Local pid:
pubs:195503
Deposit date:
2016-12-18

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