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Increased expression of surface IgM but not IgD or IgG on human B cells in response to IL-4.

Abstract:

Surface IgM (sIgM) was increased up to 10 times on human tonsillar B cells activated with IL-4. No change was observed for surface IgD, IgG or IgE. Other activators of human B cells, such as TPA, EBV and anti-IgM resulted in increased expression of the low-affinity receptor for IgE (CD23), but had no effect on sIgM. IL-4 also increased sIgM expression on prolymphocytic leukaemic (PLL) B cells, whereas TPA significantly reduced the level of sIgM. The effect on sIgM thus seems specific for IL-4...

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Authors


Shields, JG More by this author
Armitage, RJ More by this author
Jamieson, BN More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Callard, RE More by this author
Journal:
Immunology
Volume:
66
Issue:
2
Pages:
224-227
Publication date:
1989-02-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:82dacb61-abfb-4ffd-b38e-1a0792cccf68
Source identifiers:
35232
Local pid:
pubs:35232

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