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Influence of neutral protease activity on human islet isolation outcome.

Abstract:

Observations in rat pancreata have revealed that enzymatic islet release is mediated by both collagenase and neutral protease (NP), a critical effector of islet integrity. Since no information is available about the effect of NP activity on islet release from the human pancreas, the present study evaluated the effect of various NP concentrations on the outcome of human islet isolation. METHODS: Following intraductal collagenase distension, pancreata obtained from adult multiorgan donors were ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Transplantation proceedings
Volume:
37
Issue:
1
Pages:
241-242
Publication date:
2005-01-01
DOI:
EISSN:
1873-2623
ISSN:
0041-1345
URN:
uuid:82d918c3-cf57-47c9-b16c-2b15224e1290
Source identifiers:
272890
Local pid:
pubs:272890

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