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Growth, collapse, and stalling in a mechanical model for neurite motility

Abstract:

Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a three-component active gel model that describes neurites in the three robust mechanical states observed experimentally: collapsed, static, and motile. These states arise from an interplay between the physical force...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1103/PhysRevE.93.032410

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More from this funder
Funding agency for:
Jerusalem, A
Grant:
306587
Seventh Framework Programme More from this funder
Publisher:
American Physical Society Publisher's website
Journal:
Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics Journal website
Volume:
93
Issue:
3
Article number:
032410
Publication date:
2016-03-18
Acceptance date:
2016-03-13
DOI:
ISSN:
1063-651X
Source identifiers:
610935
Pubs id:
pubs:610935
UUID:
uuid:82d212a7-72db-4e21-9deb-7f36d092b070
Local pid:
pubs:610935
Deposit date:
2016-03-18

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