The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.

Journal article

Retinal photoreceptors entrain the circadian system to the solar day. This photic resetting involves cAMP response element binding protein (CREB)-mediated upregulation of Per genes within individual cells of the suprachiasmatic nuclei (SCN). Our detailed understanding of this pathway is poor, and it remains unclear why entrainment to a new time zone takes several days. By analyzing the light-regulated transcriptome of the SCN, we have identified a key role for salt inducible kinase 1 (SIK1) a...

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Authors: Jagannath, A; Butler, R; Godinho, S; Couch, Y; Brown, L

• Publication status: Published
• Journal: Cell
• Volume: 154
• Issue: 5
• Pages: 1100-1111
• Publication date: 2013-08-01
• DOI: 10.1016/j.cell.2013.08.004
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Signal Transduction; Gene Knockdown Techniques; Rod Opsins; Transcription, Genetic; Mice; Suprachiasmatic Nucleus; Animals; RNA, Small Interfering; Active Transport, Cell Nucleus; Mice, Inbred C57BL; Circadian Clocks; Transcription Factors; Protein-Serine-Threonine Kinases; Circadian Rhythm; Cyclic AMP Response Element-Binding Protein