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Thesis

Metabolic control of energetics in human heart and skeletal muscle

Abstract:

Myocardial and skeletal muscle high energy phosphate metabolism is abnormal in heart failure, but the pathophysiology is not understood. Plasma non-esterified fatty acids (NEFA) increase in heart failure due to increased sympathetic drive, and regulate the transcription of mitochondrial uncoupling protein-3 (UCP3), through peroxisome proliferator-activated receptor-α. The aim of the work in this thesis was to determine whether cardiac PCr/ATP ratios and skeletal muscle PCr kinetics during e...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Keble College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
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Funding agency for:
A W Johnson
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:82c0dce6-a162-4c08-b061-3ea7f2e35134
Local pid:
ora:6323

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