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-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.

Abstract:

Tumor necrosis factor (TNF) is recognized as a central mediator of sepsis, septic shock, and multiple organ failure. These host reactions are associated with increased TNF levels in circulation, presumably due to increased TNF production. A previously described nucleotide variation at position -308 in the promoter region of the human TNF gene was shown to be associated with the clinical outcome of malaria. In this study we addressed the relevance of the -308 polymorphism for expression of the...

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Journal:
Journal of inflammation
Volume:
46
Issue:
1
Pages:
42-50
Publication date:
1995-01-01
ISSN:
1078-7852
URN:
uuid:82a941ef-c1ec-42e4-8c18-9c23613e670a
Source identifiers:
374945
Local pid:
pubs:374945

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