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Genetic evaluation of the performance of malaria parasite clearance rate metrics

Abstract:

Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) fo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jit165

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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Wellcome Trust More from this funder
NIAID NIH HHS More from this funder
NCRR NIH HHS More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
The Journal of Infectious Diseases Journal website
Volume:
208
Issue:
2
Pages:
346–350
Publication date:
2013-04-16
DOI:
ISSN:
0022-1899 and 1537-6613
Pubs id:
pubs:395915
URN:
uri:82a29bfc-9bf6-4c34-8197-1cdd551cb09c
UUID:
uuid:82a29bfc-9bf6-4c34-8197-1cdd551cb09c
Local pid:
pubs:395915
Paper number:
2

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