PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsy.

Journal article

BACKGROUND: Studies in animal models and epileptic patients have suggested that circuits of the basal ganglia may control epileptic seizures and that striatal dopaminergic transmission plays a key role in seizure interruption. Ring chromosome 20 (r[20]) epilepsy is a very homogenous type of epilepsy and is clinically characterized by long-lasting seizures suggesting a dysfunction in the seizure control system. The hypothesis that these long-lasting seizures are associated with a reduction of ...

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Authors: Biraben, A; Semah, F; Ribeiro, M; Douaud, G; Remy, P

• Journal: Neurology
• Volume: 63
• Issue: 1
• Pages: 73-77
• Publication date: 2004-07-01
• DOI: 10.1212/01.wnl.0000132840.40838.13
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: Chromosomes, Human, Pair 20; Mental Retardation; Caudate Nucleus; Ring Chromosomes; Adolescent; Fear; Dihydroxyphenylalanine; Adult; Positron-Emission Tomography; Drug Resistance; Epilepsy, Generalized; Female; Chromosome Disorders; Epilepsies, Partial; Putamen; Status Epilepticus; Magnetic Resonance Imaging; Epilepsy; Synaptic Transmission; Radiopharmaceuticals; Humans; Anticonvulsants; Male; Electroencephalography; Dopamine; Epilepsy, Tonic-Clonic