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Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1.

Abstract:

Hypoxia-inducible factor (HIF) is a transcription factor with major roles in many cellular and systemic responses to hypoxia. Activation of HIF pathways under hypoxia is mediated by suppression of the Fe(2+)- and O(2)-dependent HIF hydroxylase enzymes that normally inactivate HIFalpha subunits. Mechanisms underlying induction of HIF in normoxic conditions are less clearly understood. In human cancers, infiltrating macrophages show up-regulation of HIF and it has recently been shown that normo...

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Publication status:
Published

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Authors


Knowles, HJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Harris, AL More by this author
Journal:
Cancer research
Volume:
66
Issue:
5
Pages:
2600-2607
Publication date:
2006-03-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:826c1572-df0f-4b81-967f-dc4dab8447d8
Source identifiers:
13309
Local pid:
pubs:13309

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