Finding your niche: what has been learnt from STM studies on GI colonization.
The first step in the pathogenesis of all enteric and some systemic infections is colonization of the gastrointestinal (GI) tract. Here, we highlight the barriers to infection faced by bacteria during their attempts to become established in the GI tract, and some of the mechanisms used by microbes to overcome innate host defences. We focus in particular on insights provided by recent studies that used signature-tagged mutagenesis to identify bacterial colonization factors in a range of enteri...Expand abstract
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