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The impact of differential antiviral immunity in children and adults.

Abstract:

The course of immune maturation has evolved to favour survival at each stage of development in early life. Fetal and neonatal immune adaptations facilitate intrauterine survival and provide early postnatal protection against extracellular pathogens, but they leave infants susceptible to intracellular pathogens such as viruses that are acquired perinatally. This Review focuses on three such pathogens--HIV, hepatitis B virus and cytomegalovirus--and relates the differential impact of these infe...

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Publication status:
Published

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Publisher copy:
10.1038/nri3277

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
Journal:
Nature reviews. Immunology
Volume:
12
Issue:
9
Pages:
636-648
Publication date:
2012-09-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:825b21d4-59f3-437c-b379-09ed368712a0
Source identifiers:
349777
Local pid:
pubs:349777

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