Inhibitory effect of TIMP influences the morphology of varicose veins.

Journal article

OBJECTIVES: Imbalance of matrix metalloproteinase enzymes (MMP) and their inhibitors (TIMPs) may contribute to the development of varicose veins. We hypothesised that, histological changes in varicose vein wall correlate with alterations in expression of MMP/TIMP. METHODS: Varicose veins (n=26) were compared with great saphenous vein (GSV) segments (n=11) from arterial bypass, and with arm and neck veins from fistula and carotid operations (n=13). Varicose vein wall thickness was measured, e...

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Authors: Aravind, B; Saunders, B; Navin, T; Sandison, A; Monaco, C

• Publication status: Published
• Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
• Volume: 40
• Issue: 6
• Pages: 754-765
• Publication date: 2010-12-01
• DOI: 10.1016/j.ejvs.2010.04.028
• EISSN: 1532-2165
• ISSN: 1078-5884
• Language: English
• Keywords: London; Connective Tissue; Case-Control Studies; Humans; Hypertrophy; Young Adult; Adult; Middle Aged; Atrophy; Female; Veins; Tissue Inhibitor of Metalloproteinase-2; Male; Aged, 80 and over; Tunica Media; Tissue Inhibitor of Metalloproteinase-3; Matrix Metalloproteinase 14; Cross-Sectional Studies; Aged; Immunohistochemistry; Varicose Veins; Matrix Metalloproteinase 2