Journal article
H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.
- Abstract:
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Background
Epigenetic changes (i.e., chromatin modifications) occur during chondrogenesis and in osteoarthritis (OA). We investigated the effect of H3K27me3 demethylase inhibition on chondrogenesis and assessed its utility in cartilage tissue engineering and in understanding cartilage destruction in OA.
Methods
We used a high-content screen to assess the effect of epigenetic modifying compounds on collagen output during chondrogenesis of monolayer human mesenchyma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.7MB, Terms of use)
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- Publisher copy:
- 10.1186/s13075-016-1053-7
Authors
Funding
Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- Arthritis Research & Therapy More from this journal
- Volume:
- 18
- Issue:
- 1
- Pages:
- 158
- Publication date:
- 2016-07-01
- Acceptance date:
- 2016-06-20
- DOI:
- ISSN:
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1478-6362 and 1478-6354
- Pmid:
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27388528
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:633956
- UUID:
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uuid:82374908-747f-4174-a199-9c92fd8318e7
- Local pid:
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pubs:633956
- Source identifiers:
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633956
- Deposit date:
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2016-11-25
Terms of use
- Copyright holder:
- Snelling et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s).Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
- Licence:
- CC Attribution (CC BY)
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