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Development of ligands to target bromodomain-histone interactions

Abstract:

Histone acetylation is an epigenetic post-translational modification recognised by the bromodomain, a protein module that forms part of multi-component complexes affecting transcription. This interaction plays fundamental cellular roles, and shows association with particular diseases including inflammation and cancer. The biological roles of bromodomains and the progress of ligands developed so far has been summarised in introductory Chapter 1.

Work within the group has led to th...

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Institution:
University of Oxford
Research group:
Prof Stuart Conway
Oxford college:
Lincoln College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

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Role:
Supervisor
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:81fffe4e-846b-42c6-b1ad-540cee5c6b78
Local pid:
ora:12250

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